| 8-69 | HJ Tayfield | South Africa v England | 1956/57 | t436 |
| 7-13 | M Jansen | South Africa v Sri Lanka | 2024/25 | t2563 |
| 7-23 | HJ Tayfield | South Africa v Australia | 1949/50 | t320 |
| 7-29 | GF Bissett | South Africa v England | 1927/28 | t172 |
| 7-32 | KA Maharaj | South Africa v Bangladesh | 2021/22 | t2460 |
| 7-46 | AR Caddick | England v South Africa | 1999/00 | t1480 |
| 7-81 | M de Lange | South Africa v Sri Lanka | 2011/12 | t2026 |
| 7-84 | FA Rose | West Indies v South Africa | 1998/99 | t1437 |
| 7-100 | CV Grimmett | Australia v South Africa | 1935/36 | t251 |
| 6-38 | PM Pollock | South Africa v New Zealand | 1961/62 | t515 |
| 6-39 | M Muralitharan | Sri Lanka v South Africa | 2000/01 | t1526 |
| 6-43 | CN McCarthy | South Africa v England | 1948/49 | t306 |
| 6-43 | NAT Adcock | South Africa v Australia | 1957/58 | t447 |
| 6-50 | SM Pollock | South Africa v Pakistan | 1997/98 | t1403 |
| 6-50 | DW Steyn | South Africa v India | 2010/11 | t1987 |
| 6-51 | CL Vincent | South Africa v England | 1930/31 | t207 |
| 6-59 | NBF Mann | South Africa v England | 1948/49 | t306 |
| 6-62 | HJ Tayfield | South Africa v New Zealand | 1953/54 | t377 |
| 6-72 | DW Steyn | South Africa v West Indies | 2007/08 | t1860 |
| 6-73 | CV Grimmett | Australia v South Africa | 1935/36 | t251 |
| 6-78 | Mushtaq Ahmed | Pakistan v South Africa | 1997/98 | t1403 |
| 6-86 | SK Warne | Australia v South Africa | 2005/06 | t1792 |
| 6-100 | DW Steyn | South Africa v India | 2013/14 | t2111 |
| 6-131 | CL Vincent | South Africa v England | 1927/28 | t170 |
| 6-138 | RA Jadeja | India v South Africa | 2013/14 | t2111 |
| 5-34 | IWG Johnson | Australia v South Africa | 1949/50 | t320 |
| 5-34 | MA Starc | Australia v South Africa | 2017/18 | t2297 |
| 5-40 | AA Donald | South Africa v India | 1996/97 | t1347 |
| 5-41 | DA Allen | England v South Africa | 1964/65 | t571 |
| 5-43 | Shoaib Akhtar | Pakistan v South Africa | 1997/98 | t1403 |
| 5-48 | M Ntini | South Africa v India | 2006/07 | t1825 |
| 5-49 | WJ O'Reilly | Australia v South Africa | 1935/36 | t247 |
| 5-52 | UWMBCA Welagedara | Sri Lanka v South Africa | 2011/12 | t2026 |
| 5-54 | GP Swann | England v South Africa | 2009/10 | t1944 |
| 5-56 | M Hayward | South Africa v Pakistan | 2002/03 | t1635 |
| 5-58 | W Voce | England v South Africa | 1930/31 | t204 |
| 5-60 | BKV Prasad | India v South Africa | 1996/97 | t1347 |
| 5-61 | JH Wardle | England v South Africa | 1956/57 | t436 |
| 5-64 | PS de Villiers | South Africa v New Zealand | 1994/95 | t1280 |
| 5-66 | FJ Titmus | England v South Africa | 1964/65 | t571 |
| 5-66 | M Ntini | South Africa v West Indies | 2003/04 | t1679 |
| 5-66 | L Ambuldeniya | Sri Lanka v South Africa | 2018/19 | t2347 |
| 5-69 | B Lee | Australia v South Africa | 2005/06 | t1792 |
| 5-73 | SB Doull | New Zealand v South Africa | 1994/95 | t1280 |
| 5-73 | DW Steyn | South Africa v Sri Lanka | 2011/12 | t2026 |
| 5-76 | AS Kennedy | England v South Africa | 1922/23 | t152 |
| 5-79 | AA Donald | South Africa v Pakistan | 1997/98 | t1403 |
| 5-79 | HMRKB Herath | Sri Lanka v South Africa | 2011/12 | t2026 |
| 5-83 | EP Nupen | South Africa v England | 1927/28 | t172 |
| 5-83 | SM Pollock | South Africa v West Indies | 1998/99 | t1437 |
| 5-87 | B Mitchell | South Africa v Australia | 1935/36 | t251 |
| 5-88 | AS Kennedy | England v South Africa | 1922/23 | t150 |
| 5-93 | BKV Prasad | India v South Africa | 1996/97 | t1347 |
| 5-98 | CRD Fernando | Sri Lanka v South Africa | 2000/01 | t1526 |
| 5-100 | RTD Perks | England v South Africa | 1938/39 | t271 |
| 5-114 | R Benaud | Australia v South Africa | 1957/58 | t447 |
| 5-122 | M Muralitharan | Sri Lanka v South Africa | 2000/01 | t1526 |
| 5-123 | KA Maharaj | South Africa v Australia | 2017/18 | t2297 |
| 5-153 | DL Piedt | South Africa v England | 2015/16 | t2196 |
