| 100 | V Balakrishnan | Botswana v St Helena | Gahanga International Cricket Stadium, Kigali | 2022/23 |
| 84 | KM Motlhanka | Botswana v Ghana | Willowmoore Park Main Oval, Benoni | 2023/24 |
| 75* | KM Motlhanka | Botswana v Rwanda | Gymkhana Club Ground, Nairobi | 2023 |
| 74 | KM Motlhanka | Botswana v Sierra Leone | Gahanga International Cricket Stadium, Kigali | 2021/22 |
| 63 | R Nehonde | Botswana v Mozambique | Gahanga International Cricket Stadium, Kigali | 2021/22 |
| 60 | T Tshose | Botswana v Eswatini | Willowmoore Park Main Oval, Benoni | 2023 |
| 59 | KM Motlhanka | Botswana v Namibia | United Ground, Windhoek | 2019 |
| 56 | KM Motlhanka | Botswana v Mozambique | Willowmoore Park Main Oval, Benoni | 2022/23 |
| 55 | A Saiyed | Botswana v Eswatini | Willowmoore Park Main Oval, Benoni | 2023 |
| 55 | V Balakrishnan | Botswana v Kenya | Gymkhana Club Ground, Nairobi | 2023 |
| 54* | KM Motlhanka | Botswana v Lesotho | Integrated Polytechnic Regional Centre, Kigali City | 2022/23 |
| 53 | R Nehonde | Botswana v Kenya | Gahanga International Cricket Stadium, Kigali | 2022/23 |
| 53* | KM Motlhanka | Botswana v Malawi | Willowmoore Park Main Oval, Benoni | 2023 |
| 50 | V Balakrishnan | Botswana v Malawi | Willowmoore Park Main Oval, Benoni | 2023 |
| 49 | T Tshose | Botswana v Mozambique | Willowmoore Park Main Oval, Benoni | 2022/23 |
| 49 | R Nehonde | Botswana v Malawi | Willowmoore Park Main Oval, Benoni | 2023/24 |
| 48 | KM Motlhanka | Botswana v Malawi | Gahanga International Cricket Stadium, Kigali | 2022/23 |
| 47* | T Tshose | Botswana v Malawi | Willowmoore Park Main Oval, Benoni | 2023 |
| 47 | V Balakrishnan | Botswana v Kenya | Gymkhana Club Ground, Nairobi | 2023 |
| 45 | R Nehonde | Botswana v Tanzania | Willowmoore Park Main Oval, Benoni | 2022/23 |
| 45* | R Nehonde | Botswana v St Helena | Gahanga International Cricket Stadium, Kigali | 2022/23 |
| 45 | KM Motlhanka | Botswana v Uganda | Gymkhana Club Ground, Nairobi | 2023 |
| 44 | A Saiyed | Botswana v Kenya | Gymkhana Club Ground, Nairobi | 2023 |
| 41 | R Nehonde | Botswana v Mozambique | Willowmoore Park Main Oval, Benoni | 2022/23 |
| 41 | P Silas | Botswana v Rwanda | Gymkhana Club Ground, Nairobi | 2023 |
| 40 | I Master | Botswana v Ghana | Willowmoore Park Main Oval, Benoni | 2022/23 |
| 39 | KM Motlhanka | Botswana v Seychelles | Integrated Polytechnic Regional Centre, Kigali City | 2022/23 |
| 38 | K Modise | Botswana v Eswatini | Willowmoore Park Main Oval, Benoni | 2023 |
| 38 | A Saiyed | Botswana v Rwanda | Gymkhana Club Ground, Nairobi | 2023 |
| 37 | R Nehonde | Botswana v Tanzania | Gahanga International Cricket Stadium, Kigali | 2021/22 |
