| 257 runs | v Gloucestershire | The Brit Oval, Kennington | 2007 | a18206 |
| 220 runs | v Northamptonshire | The Kia Oval, Kennington | 2015 | a24165 |
| 205 runs | v Yorkshire | North Marine Road, Scarborough | 1994 | a8812 |
| 184 runs | v Derbyshire | Kennington Oval, Kennington | 1967 | a95 |
| 174 runs | v Nottinghamshire | The AMP Oval, Kennington | 2001 | a13557 |
| 168 runs | v Minor Counties | The Foster's Oval, Kennington | 1992 | a7530 |
| 165 runs | v Lancashire | The Foster's Oval, Kennington | 1993 | a8069 |
| 165 runs | v Hampshire | County Ground, Southampton | 1997 | a10488 |
| 165 runs | v Gloucestershire | The Kia Oval, Kennington | 2016 | a24842 |
| 164 runs | v Gloucestershire | The Brit Oval, Kennington | 2009 | a19800 |
| 159 runs | v Netherlands | The Foster's Oval, Kennington | 1996 | a9925 |
| 153 runs | v Worcestershire | County Ground, New Road, Worcester | 2017 | a25671 |
| 150 runs | v Kent | The Foster's Oval, Kennington | 1996 | a9846 |
| 143 runs | v Glamorgan | The Foster's Oval, Kennington | 1999 | a11991 |
| 141 runs | v Leicestershire | Grace Road, Leicester | 2011 | a21482 |
| 132 runs | v Buckinghamshire | The Foster's Oval, Kennington | 1998 | a11262 |
| 130 runs | v Leicestershire | The Foster's Oval, Kennington | 1997 | a10559 |
| 130 runs | v Warwickshire | Edgbaston, Birmingham | 2011 | a21475 |
| 129 runs | v Lincolnshire | London Road, Sleaford | 1983 | a3733 |
| 128 runs | v Minor Counties | Kennington Oval, Kennington | 1981 | a2970 |
| 127 runs | v Nottinghamshire | Woodbridge Road, Guildford | 2000 | a12866 |
| 125 runs | v Northamptonshire | Kennington Oval, Kennington | 1965 | a56 |
| 125 runs | v Middlesex | Kennington Oval, Kennington | 1982 | a3437 |
| 125 runs | v Lancashire | The Foster's Oval, Kennington | 1994 | a8712 |
| 123 runs | v Lincolnshire | Lindum Sports Club Ground, Lincoln | 1974 | a1223 |
| 123 runs | v Warwickshire | Whitgift School, Croydon | 2001 | a13688 |
| 120 runs | v Glamorgan | Kennington Oval, Kennington | 1969 | a154 |
| 116 runs | v Cambridge University | Kennington Oval, Kennington | 1974 | a1140 |
| 114 runs | v Middlesex | Kennington Oval, Kennington | 1964 | a35 |
| 111 runs | v Durham | Kennington Oval, Kennington | 1982 | a3370 |
| 109 runs | v Glamorgan | Sophia Gardens, Cardiff | 1970 | a351 |
| 105 runs | v British Universities | The Foster's Oval, Kennington | 1998 | a11150 |
| 105 runs | v Somerset | The Kia Oval, Kennington | 2012 | a21958 |
| 103 runs | v Warwickshire | Whitgift School, Croydon | 2000 | a12885 |
| 101 runs | v Durham | Riverside Ground, Chester-le-Street | 1998 | a11381 |
| 100 runs | v Durham | The Racecourse, Durham | 1992 | a7681 |
| 100 runs | v Scotland | The Kia Oval, Kennington | 2013 | a22737 |
