Largest Margin of Runs Defeat
| 235 runs | by Boland | Boland Park, Paarl | 2011/12 | f53684 |
| 225 runs | by Western Province | Sahara Park Newlands, Cape Town | 2007/08 | f50616 |
| 187 runs | by Eastern Province | Sahara Oval St George's, Port Elizabeth | 2006/07 | f49556 |
| 150 runs | by Eastern Province | Axxess DSL St George's, Port Elizabeth | 2009/10 | f52338 |
| 145 runs | by Western Province | Sahara Park Newlands, Cape Town | 2010/11 | f52630 |
| 130 runs | by Northern Cape | De Beers Diamond Oval, Kimberley | 2021/22 | f60569 |
| 115 runs | by North West | Absa Puk Oval, Potchefstroom | 2023/24 | f61885 |
| 109 runs | by Gauteng | Bidvest Wanderers Stadium, Johannesburg | 2016/17 | f57335 |
| 103 runs | by Northerns | City Oval, Pietermaritzburg | 2012/13 | f54651 |
| 99 runs | by Gauteng | Bidvest Wanderers Stadium, Johannesburg | 2014/15 | f56014 |
| 94 runs | by Namibia | Wanderers Cricket Ground, Windhoek | 2010/11 | f52733 |
| 77 runs | by Boland | City Oval, Pietermaritzburg | 2010/11 | f52910 |
| 72 runs | by Griqualand West | De Beers Diamond Oval, Kimberley | 2010/11 | f52702 |
| 70 runs | by South Western Districts | Recreation Ground, Oudtshoorn | 2011/12 | f53372 |
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